منابع مشابه
Transposon Silencing by piRNAs
In animal cells, small RNA molecules, called piRNAs, defend the genome against selfish DNA elements such as transposons. In this issue, Klattenhoff et al. (2009) report that an HP1 family protein, Rhino, is required for piRNA generation and transposon silencing in Drosophila germline cells. The results provide a link between heterochromatin and piRNA-mediated genome defense.
متن کاملpiRNAs, transposon silencing, and Drosophila germline development
Transposons are prominent features of most eukaryotic genomes and mobilization of these elements triggers genetic instability. Transposon silencing is particularly critical in the germline, which maintains the heritable genetic complement. Piwi-interacting RNAs (piRNAs) have emerged as central players in transposon silencing and genome maintenance during germline development. In particular, res...
متن کاملAn epigenetic role for maternally inherited piRNAs in transposon silencing.
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic information. Crosses between Drosophila strains that differ in the presence of a particular transposon can produce sterile progeny, a phenomenon called hybrid dysgenesis. This phenotype manifests itself only if the tr...
متن کاملA Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Piwi proteins specify an animal-specific subclass of the Argonaute family that, in vertebrates, is specifically expressed in germ cells. We demonstrate that zebrafish Piwi (Ziwi) is expressed in both the male and the female gonad and is a component of a germline-specifying structure called nuage. Loss of Ziwi function results in a progressive loss of germ cells due to apoptosis during larval de...
متن کاملJulius Brennecke , in Transposon Silencing An Epigenetic Role for Maternally Inherited piRNAs
http://www.sciencemag.org/cgi/content/full/322/5906/1387 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/322/5906/1387/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...
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ژورنال
عنوان ژورنال: Cell
سال: 2009
ISSN: 0092-8674
DOI: 10.1016/j.cell.2009.08.030